Engineering poly(ethylene glycol) particles for improved biodistribution

J Cui; R De Rose; K Alt; S Alcantara; BM Paterson; K Liang; M Hu; JJ Richardson; Y Yan; CM Jeffery; RI Price; K Peter; CE Hagemeyer; PS Donnelly; SJ Kent; F Caruso

Journal article

Engineering poly(ethylene glycol) particles for improved biodistribution

J Cui, R De Rose, K Alt, S Alcantara, BM Paterson, K Liang, M Hu, JJ Richardson, Y Yan, CM Jeffery, RI Price, K Peter, CE Hagemeyer, PS Donnelly, SJ Kent, F Caruso

ACS Nano | Published : 2015

DOI: 10.1021/nn5061578

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Abstract

We report the engineering of poly(ethylene glycol) (PEG) hydrogel particles using a mesoporous silica (MS) templating method via tuning the PEG molecular weight, particle size, and the presence or absence of the template and investigate the cell association and biodistribution of these particles. An ex vivo assay based on human whole blood that is more sensitive and relevant than traditional cell-line based assays for predicting in vivo circulation behavior is introduced. The association of MS@PEG particles (template present) with granulocytes and monocytes is higher compared with PEG particles (template absent). Increasing the PEG molecular weight (from 10 to 40 kDa) or decreasing the PEG p..

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University of Melbourne Researchers

Rob De Rose Author

Karlheinz Peter Author

Paul Donnelly Author

Stephen Kent Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by the Australian Research Council under the Australian Laureate Fellowship (F.C., 120100030), Discovery Project (F.C., 130101846), Super Science Fellowship (F.C., FS110200025), Discovery Early Career Researcher Award (Y.Y., DE130100488), Future Fellowship (K.P., FT0992210), and by the National Health and Medical Research Council (NHMRC) program (S.J.K., 510448), project (K.P. and C.E.H., 1029249), and fellowship awards (S.J.K., 508937). This research was also funded by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036). R.D. is supported by the NHMRC Career Development Fellowship (APP1011578), K.A. is supported by the German Research Foundation (Al 1521/1-1), and C.E.H. is supported by a National Heart Foundation Career Development Fellowship (CR 11M 6066). The work was also supported in part by the Victorian Government's Operational Infrastructure Support Program, Monash Biomedical Imaging and Victoria's Science Agenda Strategic Project Fund. We also acknowledge Clarity Pharmaceuticals for supply and delivery of the <SUP>64</SUP>Cu, and Benjamin Hibbs (The University of Melbourne) for help in acquiring the high-resolution fluorescence images.